Achieving High Resolution LC Separations of Long-mer (>60mer) Oligonucleotides

Broadcast Date: May 25, 2023
Time: 8:00 am PT, 11:00 am ET, 17:00 CET

As nucleic acid therapeutics continue to expand and diversify, there is a growing need to achieve higher resolution separations of longer oligonucleotides. Specific examples include characterization and impurities analysis of single guide RNA for gene editing (sgRNA; typically 100-150mer), and mRNA polyA tail analysis to characterize polyA tail length and polydispersity (typically in the 90-130mer range).

In this webinar, Dr. Martin Gilar will review tools and techniques that improve the resolution of long-mer oligonucleotide separations and will demonstrate data obtained for both the characterization and impurities analysis of sgRNA as well as polyA tail length and heterogeneity analysis.

A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelist.