https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/13/issue/1
Acta Pharmaceutica Sinica B (APSB) was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high-quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Articles of interest in this issue include:
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients by Solène Marie, Kayla L. Frost, Raymond K. Hau et al. (https://doi.org/10.1016/j.apsb.2022.08.018). Expression of several hepatic metabolizing enzymes and drug transporters are altered in NASH patients. Therefore, this review identifies drugs that may exhibit disrupted pharmacokinetics based on their ADME properties.
Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach by Lingjie Bao, Zhe Wang, Zhenxing Wu et al. (https://doi.org/10.1016/j.apsb.2022.05.004). A multi-task graph isomorphism network model and related online web server were developed to predict the kinome-wide polypharmacology effects of small molecules with high accuracy.
Melatonin alleviates alcoholic liver disease via EGFR–BRG1–TERT axis regulation by Zhaodi Che, Yali Song, Chengfang Xu et al. (https://doi.org/10.1016/j.apsb.2022.06.015). Melatonin alleviates ethanol-induced liver steatosis, cell death, and inflammation through a direct binding and regulation of hepatocyte surface EGFR, to inhibit nuclear BRG1 expression and enhance downstream TERT activity.
Other articles include:
Review Articles
Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury: Cumulative evidence for future cardioprotective strategies
Panat Yanpiset, Chayodom Maneechote, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, … Nipon Chattipakorn
Original Articles
CYP1B1-derived epoxides modulate the TRPA1 channel in chronic pain
Lili Sun, Jie Zhang, Changshan Niu, Cassandra E. Deering-
Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids
Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, … José Miguel Vela
Dihydrotanshinone I preconditions myocardium against ischemic injury via PKM2 glutathionylation sensitive to ROS
Xunxun Wu, Lian Liu, Qiuling Zheng, Hui Ye, … Ping Li
Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1–Notch1
Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, … Zhaoliang Su
Targeting macrophagic 17β-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease
Xiaoyu Dong, Yiting Feng, Dongqin Xu, Mengya Zhang, … Jie Ping
PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism
Mingming Sun, Leilei Li, Yujia Niu, Yingzhi Wang, … Changliang Shan
Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virus-induced oxidative stress
Eun-Bin Kwon, Wei Li, Young Soo Kim, Buyun Kim, … Jang-Gi Choi
Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy
Yubi Lin, Ruonan Liu, Yanling Huang, Zhe Yang, … Geyang Xu
Fluorine-thiol displacement probes for acetaminophen’s hepatotoxicity
Benjamin L. Prather, Shuyue Ji, Yue Zhao, Femil Joseph Shajan, … Rongsheng E. Wang
Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4
Ahmed Haider, Xiaoyun Deng, Olivia Mastromihalis, Stefanie K. Pfister, … Steven H. Liang
Bile duct ligation differently regulates protein expressions of organic cation transporters in intestine, liver and kidney of rats through activation of farnesoid X receptor by cholate and bilirubin
Shijin Hong, Shuai Li, Xiaoyan Meng, Ping Li, … Li Liu
Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O– to C-glycoside isomerase
Pengfei He, Sha Wang, Sen Li, Siqi Liu, … Wenfu Ma
Late-stage cascade of oxidation reactions during the biosynthesis of oxalicine B in Penicillium oxalicum
Tao Zhang, Guowei Gu, Guodong Liu, Jinhua Su, … Liyan Yu
Functional characterization of a cycloartenol synthase and four glycosyltransferases in the biosynthesis of cycloastragenol-type astragalosides from Astragalus membranaceus
Yangyang Duan, Wenyu Du, Zhijun Song, Ridao Chen, … Jungui Dai
Bilayer hydrogel dressing with lysozyme-enhanced photothermal therapy for biofilm eradication and accelerated chronic wound repair
Yizhen Wang, Qijun Lv, You Chen, Langtao Xu, … Bo Liu
A neutrophil-biomimic platform for eradicating metastatic breast cancer stem-like cells by redox microenvironment modulation and hypoxia-triggered differentiation therapy
Yongchao Chu, Yifan Luo, Boyu Su, Chao Li, … Tao Sun
Predatory bacterial hydrogels for topical treatment of infected wounds
Yan Liu, Bo Zhuang, Bochuan Yuan, Hui Zhang, … Yiguang Jin
Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy
Zimo Liu, Xuefei Zhou, Qi Li, Youqing Shen, … Xiangrui Liu
Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency
Li Yang, Qingyun Liu, Xinhui Wang, Nansha Gao, … Xiaowei Zeng
All-stage targeted therapy for the brain metastasis from triple-negative breast cancer
Zimiao Luo, Sunyi Wu, Jianfen Zhou, Weixia Xu, … Weiyue Lu
Highly sensitive H2O2-scavenging nano-bionic system for precise treatment of atherosclerosis
Xiaoyu Liang, Huiyang Li, Xuanling Li, Xinxin Tian, … Jing Yang
Pathologically triggered in situ aggregation of nanoparticles for inflammation-targeting amplification and therapeutic potentiation
Qiang Nie, Chenwen Li, Yu Wang, Yi Hu, … Jianxiang Zhang
Chlorella sp.-ameliorated undesirable microenvironment promotes diabetic wound healing
Hangyi Wu, Pei Yang, Aiqin Li, Xin Jin, … HuiXia Lv
Sialic acid-mediated photochemotherapy enhances infiltration of CD8+ T cells from tumor-draining lymph nodes into tumors of immunosenescent mice
Dezhi Sui, Changzhi Li, Xueying Tang, Xianmin Meng, … Yanzhi Song
Letter to the editor
Rational design and crystallographic analysis of novel isoform-selective TRKA inhibitors for cancer therapy
Guan Wang, Yongya Wu, Chengyong Wu, Wen Shuai, … Liang Ouyang
# # # # # #
The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.
For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/
Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board
APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).
Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).
CiteScore: 15.9
Impact Factor: 14.903
JIF without self-citation: 13.888
ISSN 2211-3835
# # # # #
