Antiverse identifies therapeutic antibodies targeting GPCRs

Antiverse Ltd has announced the successful identification of functional antibody clusters targeting two G-protein-coupled receptors (GPCRs), both displaying versatile binding profiles and nanomolar affinity. 

The company, which was featured as one of our five Welsh biotech startups making waves in 2023, also announced it has raised $3 million funding, which will enable in-house development of the antibodies showing the highest affinity blocking function, making them ideal starting points as therapeutic assets.

The antibodies were identified using Antiverse’s proprietary computational antibody drug discovery platform, which uses machine learning to model antibody-antigen interactions and design de novo antibodies. 

The platform was used to identify a diverse set of binders to two structurally distinct GPCRs, and following fluorescence-activated cell sorting (FACS), eight antibodies were identified as human GPCR binders (Figure 1). Seven of these binders were confirmed as antagonists (Figure 2), blocking GPCR activity.

Figure 1: FACS analysis of hGPCR expressing cell lines conjugated with antibody candidates. Data in blue represents specific binders,

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