Life Sciences
Psilera Unveils Novel, Non-Hallucinogenic Psilocybin Derivative PSIL-006 As Lead Clinical Candidate
Psilera, a biopharmaceutical company developing next-generation mental health treatments for take home use, announces the selection of their lead clinical…
Psilera, a biopharmaceutical company developing next-generation mental health treatments for take home use, announces the selection of their lead clinical candidate, PSIL-006. This novel drug with similar characteristics to psilocybin while lacking hallucinogenic effects was derived from Psilera’s in-house discovery pipeline.
When compared directly in preclinical in vivo studies, PSIL-006 was able to induce rapid and positive behavioral changes representative of alcohol use disorder (AUD), anxiety, depression, and cognitive disorders similar to the psilocybin mimic, psilacetin.
In multiple proof-of-concept clinical trials, psilocybin has shown positive efficacy for addiction (AUD and nicotine dependence), depression, and end-of-life anxiety. PSIL-006 represents a non-hallucinogenic alternative to psilocybin. With fewer side effects, PSIL-006 could enable take-home dosing to greatly enhance treatment scale over psilocybin and other psychedelics.
PSIL-006 is a non-hallucinogenic serotonin receptor 6 (5-HT6) and 2A (5-HT2A) dual agonist that selectively reduces hallucinogenic effects while retaining rapid therapeutic benefits. The unique activity seen in preclinical models represents a novel mechanism of action for addiction and psychiatric disorders.
“PSIL-006 epitomizes our patient-centric values at Psilera. Our focus is to provide new treatment options to a larger patient population for difficult to treat mental illnesses. We are enthusiastic by the data with PSIL-006 and look forward to providing further updates as we progress towards the clinic.”
Dr. Chris Witowski, Co-Founder and CEO at Psilera
About Psilera
Psilera leverages a world-class scientific and executive team to reimagine psychoactive natural products into effective and insurance-backed take home therapies. Their drug discovery engine combines novel syntheses of new compounds with a technology-enabled platform to design next-generation neurological drugs at the atomic level. Psilera has developed new compound classes which are non-hallucinogenic with rapid therapeutic benefits. Psilera’s mission is to enhance the lives of patients by delivering new treatment options with fewer side effects in psychiatric, addiction, and neurodegenerative disorders. Psilera is defining the new era in mindful medicine.
biopharmaceutical
psychedelics
psilocybin
psychoactive
depression
anxiety
serotonin
hallucinogenic
Wittiest stocks:: Avalo Therapeutics Inc (NASDAQ:AVTX 0.00%), Nokia Corp ADR (NYSE:NOK 0.90%)
There are two main reasons why moving averages are useful in forex trading: moving averages help traders define trend recognize changes in trend. Now well…
Spellbinding stocks: LumiraDx Limited (NASDAQ:LMDX 4.62%), Transocean Ltd (NYSE:RIG -2.67%)
There are two main reasons why moving averages are useful in forex trading: moving averages help traders define trend recognize changes in trend. Now well…
Asian Fund for Cancer Research announces Degron Therapeutics as the 2023 BRACE Award Venture Competition Winner
The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition….