Twist Bioscience Announces Technology Early Access of Enhanced Whole Genome Sequencing Solution at AGBT

Twist Bioscience Corporation, a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, announced technology early access of the Twist enhanced Whole Genome Sequencing (eWGS) solution focused on non-human genomics applications, at the Advances in Genome Biology and Technology (AGBT) 2023 General Meeting in Hollywood, Florida. eWGS is a novel solution that enables researchers to obtain simultaneous low-pass whole genome data together with deep coverage of selected regions, in a high-throughput and cost-effective workflow.

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“In agricultural genomics, researchers constantly have to make a tradeoff between cost and insight. Deep sequencing across entire genomes is cost prohibitive, forcing researchers to turn to less costly approaches like genotyping by sequencing, microarrays, or low-pass WGS. These methods impose limits on the resolution, accuracy, or flexibility of experiments,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “With our eWGS solution, researchers can now get all the information they need without compromising on cost or data, enabling our customers to push new boundaries in trait selection, breeding and other applications.”

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The eWGS workflow starts with a modified Twist 96-plex library preparation kit that prepares 96 samples for sequencing in a single tube. This is followed by single-tube 96-plex enrichment on an aliquot of the library, using a customized panel to further enrich targets requiring more coverage. The original and enriched libraries are then combined into a single sequencer-ready pool that has both low whole genome coverage between 0.5x and 4x as well as high target-specific coverage. Researchers can tune the differential in coverage between low-pass and high-pass sites to fit their needs. Preparing and enriching 96 samples at a time for sequencing in a single pool can enable a high-throughput workflow and may reduce costs by using less materials and resources.

Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery. Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research.

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